Dance Your Dissertation 2010 - Daria Neidre

in vitro testing

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The Use of Autologous Adipose and Bone Marrow Derived Stem Cells in a Point of Care Goat Non-Instrumented Posterolateral Lumbar There are over 185, 000 spinal fusions performed each year. The gold standard for these fusions is the Iliac Crest Bone Graft (ICBG) where a potion of the bone is harvested from the iliac crest and implanted into the lumbar fusion site. This procedure has many complications including donor site necrosis, donor site morbidity and long-term pain and discomfort for the patient. An alternative to ICBG is harvesting bone marrow through iliac crest aspiration, which contains adult mesenchymal stem cells (BMSC) that facilitate bone growth when placed on an appropriate bone-like scaffold. Recently, adult stem cells derived from adipose (fat) tissue (ADSC) have demonstrated similar abilities of bone growth to those isolated from the bone marrow. Reserves for isolation of BMSCs are small due to the limited volume of marrow within the iliac crest. Adipose tissue has demonstrated easier access of tissue, higher stem cell number yield, and larger amounts of tissue to isolate stem cells, without the problems associated with BMSC and ICBG. We aimed to characterize and compare in vitro stem cells isolated from bone marrow and fat tissue and in vivo implantation in a non-instrumented posterolateral spinal fusion in a goat large animal model as a human translational study. The goat model is a common large animal model for orthopaedics as they are similar to humans...


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Artist: in vitro testing
Video title: Dance Your Dissertation 2010 - Daria Neidre
Views: 410
Submitted by: toxcafe